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Biotransformation of Phthalazine by Fusarium moniliforme and Cunninghamela elegans

John B. Sutherland, James P. Freeman, Anna J. Williams and Joanna Deck
Mycologia
Vol. 91, No. 1 (Jan. - Feb., 1999), pp. 114-116
DOI: 10.2307/3761198
Stable URL: http://www.jstor.org/stable/3761198
Page Count: 3
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Biotransformation of Phthalazine by Fusarium moniliforme and Cunninghamela elegans
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Abstract

Fusarium moniliforme and Cunninghamella elegans were grown in fluid Sabouraud medium at 28 C. They were dosed with 6.2 mM phthalazine and then incubated for 3 d with shaking at 125 rpm. After extraction with ethyl acetate, the metabolites were purified by HPLC and identified by the UV/visible, mass, and NMR spectra. The results show that F. moniliforme oxidized about 42% of the phthalazine to 1 (2H)-phthalazinone (= 1-hydroxyphthalazine) and that C. elegans oxidized about 6% of the phthalazine to a novel metabolite, phthalazine N-oxide (= phthalazine 2-oxide).

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