You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Biotransformation of Phthalazine by Fusarium moniliforme and Cunninghamela elegans
John B. Sutherland, James P. Freeman, Anna J. Williams and Joanna Deck
Vol. 91, No. 1 (Jan. - Feb., 1999), pp. 114-116
Published by: Mycological Society of America
Stable URL: http://www.jstor.org/stable/3761198
Page Count: 3
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Fusarium moniliforme and Cunninghamella elegans were grown in fluid Sabouraud medium at 28 C. They were dosed with 6.2 mM phthalazine and then incubated for 3 d with shaking at 125 rpm. After extraction with ethyl acetate, the metabolites were purified by HPLC and identified by the UV/visible, mass, and NMR spectra. The results show that F. moniliforme oxidized about 42% of the phthalazine to 1 (2H)-phthalazinone (= 1-hydroxyphthalazine) and that C. elegans oxidized about 6% of the phthalazine to a novel metabolite, phthalazine N-oxide (= phthalazine 2-oxide).
Mycologia © 1999 Mycological Society of America