If you need an accessible version of this item please contact JSTOR User Support

Biotransformation of Phthalazine by Fusarium moniliforme and Cunninghamela elegans

John B. Sutherland, James P. Freeman, Anna J. Williams and Joanna Deck
Mycologia
Vol. 91, No. 1 (Jan. - Feb., 1999), pp. 114-116
DOI: 10.2307/3761198
Stable URL: http://www.jstor.org/stable/3761198
Page Count: 3
  • Download PDF
  • Cite this Item

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If you need an accessible version of this item please contact JSTOR User Support
Biotransformation of Phthalazine by Fusarium moniliforme and Cunninghamela elegans
Preview not available

Abstract

Fusarium moniliforme and Cunninghamella elegans were grown in fluid Sabouraud medium at 28 C. They were dosed with 6.2 mM phthalazine and then incubated for 3 d with shaking at 125 rpm. After extraction with ethyl acetate, the metabolites were purified by HPLC and identified by the UV/visible, mass, and NMR spectra. The results show that F. moniliforme oxidized about 42% of the phthalazine to 1 (2H)-phthalazinone (= 1-hydroxyphthalazine) and that C. elegans oxidized about 6% of the phthalazine to a novel metabolite, phthalazine N-oxide (= phthalazine 2-oxide).

Page Thumbnails

  • Thumbnail: Page 
114
    114
  • Thumbnail: Page 
115
    115
  • Thumbnail: Page 
116
    116