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Defective CD8 T Cell Memory Following Acute Infection without CD4 T Cell Help

Joseph C. Sun and Michael J. Bevan
Science
New Series, Vol. 300, No. 5617 (Apr. 11, 2003), pp. 339-342
Stable URL: http://www.jstor.org/stable/3834156
Page Count: 4
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Defective CD8 T Cell Memory Following Acute Infection without CD4 T Cell Help
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Abstract

The CD8+ cytotoxic T cell response to pathogens is thought to be CD4+ helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4+ T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8+ T cells from normal mice can respond rapidly, but memory CD8+ T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.

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