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Excitatory Effect of GABAergic Axo-Axonic Cells in Cortical Microcircuits

János Szabadics, Csaba Varga, Gábor Molnár, Szabolcs Oláh, Pál Barzó and Gábor Tamás
Science
New Series, Vol. 311, No. 5758 (Jan. 13, 2006), pp. 233-235
Stable URL: http://www.jstor.org/stable/3843264
Page Count: 3
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Abstract

Axons in the cerebral cortex receive synaptic input at the axon initial segment almost exclusively from β-aminobutyric acid-releasing (GABAergic) axo-axonic cells (AACs). The axon has the lowest threshold for action potential generation in neurons; thus, AACs are considered to be strategically placed inhibitory neurons controlling neuronal output. However, we found that AACs can depolarize pyramidal cells and can initiate stereotyped series of synaptic events in rat and human cortical networks because of a depolarized reversal potential for axonal relative to perisomatic GABAergic inputs. Excitation and signal propagation initiated by AACs is supported by the absence of the potassium chloride cotransporter 2 in the axon.

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