Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number

Steven W. Flavell, Christopher W. Cowan, Tae-Kyung Kim, Paul L. Greer, Yingxi Lin, Suzanne Paradis, Eric C. Griffith, Linda S. Hu, Chinfei Chen and Michael E. Greenberg
Science
New Series, Vol. 311, No. 5763 (Feb. 17, 2006), pp. 1008-1012
Stable URL: http://www.jstor.org/stable/3843567
Page Count: 5
  • More info
  • Cite this Item
Preview not available
Preview not available

Abstract

In the mammalian nervous system, neuronal activity regulates the strength and number of synapses formed. The genetic program that coordinates this process is poorly understood. We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity- and calcineurin-dependent manner as hippocampal neurons formed synapses. In response to increased neuronal activity, calcium influx into neurons induced the activation of the calcium/calmodulin-regulated phosphatase calcineurin, which dephosphorylated and activated MEF2. When activated, MEF2 promoted the transcription of a set of genes, including arc and synGAP, that restrict synapse number. These findings define an activity-dependent transcriptional program that may control synapse number during development.

Page Thumbnails

  • Thumbnail: Page 
1008
    1008
  • Thumbnail: Page 
1009
    1009
  • Thumbnail: Page 
1010
    1010
  • Thumbnail: Page 
1011
    1011
  • Thumbnail: Page 
1012
    1012