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αE-Catenin Controls Cerebral Cortical Size by Regulating the Hedgehog Signaling Pathway

Wen-Hui Lien, Olga Klezovitch, Tania E. Fernandez, Jeff Delrow and Valeri Vasioukhin
Science
New Series, Vol. 311, No. 5767 (Mar. 17, 2006), pp. 1609-1612
Stable URL: http://www.jstor.org/stable/3845671
Page Count: 4
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αE-Catenin Controls Cerebral Cortical Size by Regulating the Hedgehog Signaling Pathway
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Abstract

During development, cells monitor and adjust their rates of accumulation to produce organs of predetermined size. We show here that central nervous system-specific deletion of the essential adherens junction gene, αE-catenin, causes abnormal activation of the hedgehog pathway, resulting in shortening of the cell cycle, decreased apoptosis, and cortical hyperplasia. We propose that αE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex.

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