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Hypothalamic mTOR Signaling Regulates Food Intake
Daniela Cota, Karine Proulx, Kathi A. Blake Smith, Sara C. Kozma, George Thomas, Stephen C. Woods and Randy J. Seeley
New Series, Vol. 312, No. 5775 (May 12, 2006), pp. 927-930
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/3846211
Page Count: 4
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The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that regulates cell-cycle progression and growth by sensing changes in energy status. We demonstrated that mTOR signaling plays a role in the brain mechanisms that respond to nutrient availability, regulating energy balance. In the rat, mTOR signaling is controlled by energy status in specific regions of the hypothalamus and colocalizes with neuropeptide Y and proopiomelanocortin neurons in the arcuate nucleus. Central administration of leucine increases hypothalamic mTOR signaling and decreases food intake and body weight. The hormone leptin increases hypothalamic mTOR activity, and the inhibition of mTOR signaling blunts leptin's anorectic effect. Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake.
Science © 2006 American Association for the Advancement of Science