Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Hypothalamic mTOR Signaling Regulates Food Intake

Daniela Cota, Karine Proulx, Kathi A. Blake Smith, Sara C. Kozma, George Thomas, Stephen C. Woods and Randy J. Seeley
Science
New Series, Vol. 312, No. 5775 (May 12, 2006), pp. 927-930
Stable URL: http://www.jstor.org/stable/3846211
Page Count: 4
  • More info
  • Cite this Item
Hypothalamic mTOR Signaling Regulates Food Intake
Preview not available

Abstract

The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that regulates cell-cycle progression and growth by sensing changes in energy status. We demonstrated that mTOR signaling plays a role in the brain mechanisms that respond to nutrient availability, regulating energy balance. In the rat, mTOR signaling is controlled by energy status in specific regions of the hypothalamus and colocalizes with neuropeptide Y and proopiomelanocortin neurons in the arcuate nucleus. Central administration of leucine increases hypothalamic mTOR signaling and decreases food intake and body weight. The hormone leptin increases hypothalamic mTOR activity, and the inhibition of mTOR signaling blunts leptin's anorectic effect. Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake.

Page Thumbnails

  • Thumbnail: Page 
927
    927
  • Thumbnail: Page 
928
    928
  • Thumbnail: Page 
929
    929
  • Thumbnail: Page 
930
    930