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Activated Signal Transduction Kinases Frequently Occupy Target Genes

Dmitry K. Pokholok, Julia Zeitlinger, Nancy M. Hannett, David B. Reynolds and Richard A. Young
Science
New Series, Vol. 313, No. 5786 (Jul. 28, 2006), pp. 533-536
Stable URL: http://www.jstor.org/stable/3846820
Page Count: 4
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Activated Signal Transduction Kinases Frequently Occupy Target Genes
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Abstract

Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which these pathways regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protein kinase A subunits become physically associated with the genes that they regulate in the yeast (Saccharomyces cerevisiae) genome. The ability to detect this interaction of signaling kinases with target genes can be used to more precisely and comprehensively map the regulatory circuitry that eukaryotic cells use to respond to their environment.

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