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Antibody Responses to Vaccination with WRL 105 Strain Live Influenza Vaccine in Previously Vaccinated and Unvaccinated Volunteers

A. E. J. Evans, R. L. L. Simmons, R. D. Ferris, S. K. Hasell, E. Letley and D. S. Freestone
The Journal of Hygiene
Vol. 82, No. 3 (Jun., 1979), pp. 489-495
Stable URL: http://www.jstor.org/stable/3862296
Page Count: 7
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Antibody Responses to Vaccination with WRL 105 Strain Live Influenza Vaccine in Previously Vaccinated and Unvaccinated Volunteers
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Abstract

Intranasal vaccination with a single 0·5 ml dose of $10^{7.0}$ EID 50 WRL 105 strain live influenza vaccine elicited four-fold or greater increases in circulating homotypic haemagglutinating inhibiting (HAI) antibody in 60 (64·5%) of 93 volunteers, or in 58 (74·4%) of 78 volunteers with HAI antibody titres before vaccination of ≤ 1/20. In comparison, in a group of volunteers vaccinated 9 months previously re-vaccination elicited antibody responses in only 4 (6·9%) of 58 volunteers, or in 3 (14·3%) of 21 volunteers with antibody titres before vaccination of ≤ 1/20. Titres of vaccine-induced antibody and antibody resulting from earlier natural infection appeared to fall slowly and at equivalent rates over a 9 month period.

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