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Influenza B at Christ's Hospital: Natural Antibody to Influenza B Estimated by Radial Haemolysis

E. A. Grilli and J. R. Davies
The Journal of Hygiene
Vol. 87, No. 2 (Oct., 1981), pp. 211-218
Stable URL: http://www.jstor.org/stable/3862607
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Influenza B at Christ's Hospital: Natural Antibody to Influenza B Estimated by Radial Haemolysis
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Abstract

The technique of radial haemolysis (SRH) was used to assess the response to infection with different strains of influenza B virus, to determine the persistence of antibody following such infection and to examine sera from boys entering school at age 11 years. The technique detected 95% of infections and in primary infection the antibody response was mainly to the infecting strain. Re-infections resulted in a broad response, both to the homotypic strain and to strains more distantly related. Antibody to the homotypic strain persisted for at least 3 years but in some individuals the reaction with heterotypic strains tended to become weaker - resulting in zones of incomplete lysis - or was lost. Examination of the sera collected on entry to the school showed that about 60% of the boys bled before B/Hong Kong became widespread in the United Kingdom had antibody to strains representative of those isolated in the 1960s and few boys had antibody to B/Hong Kong. After 1974 antibody to B/Hong Kong and later strains became more common while antibody to earlier strains was less frequently detected. The significance of the results as an estimate of past experience is discussed.

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