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Effects of Ceftriaxone on Faecal Flora: Analysis by Micromorphometry
B. C. Meijer, G. J. Kootstra, D. G. Geertsma and M. H. F. Wilkinson
Epidemiology and Infection
Vol. 106, No. 3 (Jun., 1991), pp. 513-521
Published by: Cambridge University Press
Stable URL: http://www.jstor.org/stable/3864167
Page Count: 9
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In order to elucidate the effect of ceftriaxone therapy on the morphology of gut microflora, 11 human volunteers were treated with ceftriaxone, 1 g daily, given intramuscularly in one dose. Treatment continued for 5 days. Faecal microflora was analysed by digital image processing before, during and after the treatment period. We derived simple numerical parameters which describe the morphologic composition of the flora. They were significantly influenced by the antibiotic, and returned to their baseline values more than 7 days after treatment was stopped. The procedure holds promise for clinical application.
Epidemiology and Infection © 1991 Cambridge University Press