Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Estrogen and Androgen Receptor Proteins in Embryonic and Neonatal Brain: Hypotheses for Roles in Sexual Differentiation and Behavior

Thomas O. Fox, Christine C. Vito and Steven J. Wieland
American Zoologist
Vol. 18, No. 3 (Summer, 1978), pp. 525-537
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/3882311
Page Count: 13
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Estrogen and Androgen Receptor Proteins in Embryonic and Neonatal Brain: Hypotheses for Roles in Sexual Differentiation and Behavior
Preview not available

Abstract

We have demonstrated and partially characterized putative estrogen and androgen receptors from mouse hypothalamus for a range of perinatal ages. For the first time, estrogen and androgen receptors from embryonic mouse and rat hypothalamus are described and characterized; they display similar parameters as the receptor proteins of adult mice and rats. The ontogeny of these proteins is discussed in the context of models for the control of the "critical period" of sexual differentiation of the brain. The androgen-binding proteins, presumed to be receptors, are compared for hypothalamus and kidney and for the androgen-resistant mutant mouse, testicular feminization (Tfm). The putative receptor forms that are observed help to define the possible function of brain androgen receptors during sexual differentiation. Development and modification of DNA-cellulose chromatography for the affinity separation of steroid receptors of brain is described. The methods allow complete separations of receptor proteins from non-receptor, steroid-binding proteins and subsequent analysis of the resultant receptors.

Page Thumbnails

  • Thumbnail: Page 
525
    525
  • Thumbnail: Page 
526
    526
  • Thumbnail: Page 
527
    527
  • Thumbnail: Page 
528
    528
  • Thumbnail: Page 
529
    529
  • Thumbnail: Page 
530
    530
  • Thumbnail: Page 
531
    531
  • Thumbnail: Page 
532
    532
  • Thumbnail: Page 
533
    533
  • Thumbnail: Page 
534
    534
  • Thumbnail: Page 
535
    535
  • Thumbnail: Page 
536
    536
  • Thumbnail: Page 
537
    537