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Cell Interactions during Early Sea Urchin Development

Fred H. Wilt, Brian Livingston and Oded Khaner
American Zoologist
Vol. 35, No. 4 (Sep., 1995), pp. 353-357
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/3884209
Page Count: 5
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Cell Interactions during Early Sea Urchin Development
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Abstract

The sea urchin embryo is known to show considerable powers of regulation. This developmental plasticity has been taken to indicate that many of the early events of determination are a result of cell interactions. We inquire here whether such interactions do in fact occur during normal development, what is their character, and possible mechanisms of these interactions. Attempts from our laboratory to answer these questions will be reviewed. Experiments in which marked cells are recombined with one another confirm the remarkable plasticity of the animal hemisphere cells of these early embryos. The effect of vegetal cells other than micromeres is to suppress formation of gut and spicules in animal hemisphere cells. Micromeres differentiate into spicules in any location and stimulate animal cells to form gut. Li ion stimulates the formation of gut and spicules in cells from the animal hemisphere. Experiments with phorbol esters and myo-inositol support the idea that the inositol tris phosphate second messenger cycle, acting on protein kinase C, is a key component of these cell interactions.

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