You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Intravenous Injection of Soluble Antigen Induces Thymic and Peripheral T-Cell Apoptosis
Roland S. Liblau, Roland Tisch, Kevan Shokat, Xiao-Dong Yang, Nicole Dumont, Christopher C. Goodnow and Hugh O. McDevitt
Proceedings of the National Academy of Sciences of the United States of America
Vol. 93, No. 7 (Apr. 2, 1996), pp. 3031-3036
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/39110
Page Count: 6
You can always find the topics here!Topics: T lymphocytes, T cell antigen receptors, Antigens, Apoptosis, Thymocytes, Ova, Immune tolerance, Lymph nodes, Transgenic animals, Antigen presenting cells
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
The mechanism by which tolerance is induced via systemic administration of high doses of aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific for the influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138. After intravenous injection of 750 (but not 75) μ g of HA peptide, a state of hyporesponsiveness was rapidly induced. In the thymus, in situ apoptosis in the cortex and at the corticomedullary junction was responsible for a synchronous and massive deletion of CD4+ CD8+ thymocytes. In secondary lymphoid organs, HA-reactive T cells were initially activated but were hyporesponsive at the single cell level. After 3 days, however, those cells were rapidly deleted, at least partially, through an apoptotic process. Therefore, both thymic and peripheral apoptosis, in addition to T-cell receptor desensitization, contribute to high-dose tolerance.
Proceedings of the National Academy of Sciences of the United States of America © 1996 National Academy of Sciences