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POU Domain Factor Brn-3b is Required for the Development of a Large Set of Retinal Ganglion Cells
Lin Gan, Mengqing Xiang, Lijuan Zhou, Daniel S. Wagner, William H. Klein and Jeremy Nathans
Proceedings of the National Academy of Sciences of the United States of America
Vol. 93, No. 9 (Apr. 30, 1996), pp. 3920-3925
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/39168
Page Count: 6
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The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is first observed in presumptive ganglion cell precursors as they begin to migrate from the zone of dividing neuroblasts to the future ganglion cell layer, and that targeted disruption of the Brn-3b gene leads in the homozygous state to a selective loss of 70% of retinal ganglion cells. In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types.
Proceedings of the National Academy of Sciences of the United States of America © 1996 National Academy of Sciences