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Early Migration of Sarcocystis neurons in Ponies Fed Sporocysts
E. Elitsur, A. E. Marsh, S. M. Reed, J. P. Dubey, M. J. Oglesbee, J. E. Murphy and W. J. A. Saville
The Journal of Parasitology
Vol. 93, No. 5 (Oct., 2007), pp. 1222-1225
Stable URL: http://www.jstor.org/stable/40058849
Page Count: 4
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Sarcocystis neurona is the most important cause of equine protozoal myeloencephalitis (EPM), a neurologic disease of the horse. In the present work, the kinetics of S. neurona invasion is determined in the equine model. Six ponies were orally inoculated with 250 X 10⁶ S. neurona sporocysts via nasogastric intubation and killed on days 1, 2, 3, 5, 7, and 9 postinoculation (PI). At necropsy, tissue samples were examined for S. neurona infection. The parasite was isolated from the mesenteric lymph nodes at 1, 2, and 7 days PI; the liver at 2, 5, and 7 days PI; and the lungs at 5, 7, and 9 days PI by bioassays in interferon gamma gene knock out mice (KO) and from cell culture. Microscopic lesions consistent with an EPM infection were observed in brain and spinal cord of ponies killed 7 and 9 days PI. Results suggest that S. neurona disseminates quickly in tissue of naive ponies.
The Journal of Parasitology © 2007 The American Society of Parasitologists