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Panton-Valentine Leukocidin Is Not a Virulence Determinant in Murine Models of Community-Associated Methicillin-Resistant Staphylococcus aureus Disease

Juliane Bubeck Wardenburg, Amy M. Palazzolo-Ballance, Michael Otto, Olaf Schneewind and Frank R. DeLeo
The Journal of Infectious Diseases
Vol. 198, No. 8 (Oct. 15, 2008), pp. 1166-1170
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/40254252
Page Count: 5
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Panton-Valentine Leukocidin Is Not a Virulence Determinant in Murine Models of Community-Associated Methicillin-Resistant Staphylococcus aureus Disease
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Abstract

Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CAMRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.

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