Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Genital Human Papillomavirus Prevalence and Human Papillomavirus Concordance in Heterosexual Couples Are Positively Associated with Human Immunodeficiency Virus Coinfection

Zizipho Z. A. Mbulawa, David Coetzee, Dianne J. Marais, Mercy Kamupira, Eugene Zwane, Bruce Allan, Deborah Constant, Jennifer R. Moodley, Margaret Hoffman and Anna-Lise Williamson
The Journal of Infectious Diseases
Vol. 199, No. 10 (May 15, 2009), pp. 1514-1524
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/40254591
Page Count: 11
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Genital Human Papillomavirus Prevalence and Human Papillomavirus Concordance in Heterosexual Couples Are Positively Associated with Human Immunodeficiency Virus Coinfection
Preview not available

Abstract

This study examined the concordance of genital human papillomavirus (HPV) infection in 254 heterosexually active couples and the impact of HIV coinfection. Genital HPV detection was significantly more common among HIV-infected women than among HIV-seronegative women (99 [68%] of 145 women vs. 33 [31%] of 107 women; P<.001); similarly, HPV detection was significantly more common among HIV-infected men than among HIV-seronegative men (67 [72%] of 93 and 65 [43%] of 150 men, respectively; P< .001). HIV-seronegative male partners of HIV-infected women had a significantly greater prevalence of HPV infection than did HIV-seronegative male partners of HIV-seronegative women (38 [58%] of 65 men vs. 27 [32%] of 85 men; P = .001), indicating that HIV coinfection in one partner has a significant impact on the prevalence of HPV genital infection in the other partner. HPV concordance between couples was associated with HIV infection status (P< .001, by Pearson's X² test) and was significantly higher among HIV-infected couples than among HIV-seronegative couples. Typespecific sharing of HPV was associated with HIV concordance status (P = .024). HIV-seronegative couples were more likely to share 1 HPV type and were unlikely to share > 1 type, whereas HIV-infected or HIV-discordant couples were more likely to share > 1 HPV type. Women with a high HPV load frequently shared HPV types with their male partners, suggesting that a high HPV load may play a role in HPV transmission between partners. In conclusion, HIV coinfection in one or both sexually active partners increased HPV prevalence and HPV typespecific concordance.

Page Thumbnails

  • Thumbnail: Page 
1514
    1514
  • Thumbnail: Page 
1515
    1515
  • Thumbnail: Page 
1516
    1516
  • Thumbnail: Page 
1517
    1517
  • Thumbnail: Page 
1518
    1518
  • Thumbnail: Page 
1519
    1519
  • Thumbnail: Page 
1520
    1520
  • Thumbnail: Page 
1521
    1521
  • Thumbnail: Page 
1522
    1522
  • Thumbnail: Page 
1523
    1523
  • Thumbnail: Page 
1524
    1524