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Dietary Intake of Carotenoids and Retinol and Endometrial Cancer Risk in an Italian Case–Control Study

Claudio Pelucchi, Luigino Dal Maso, Maurizio Montella, Maria Parpinel, Eva Negri, Renato Talamini, Aldo Giudice, Silvia Franceschi and Carlo La Vecchia
Cancer Causes & Control
Vol. 19, No. 10 (Dec., 2008), pp. 1209-1215
Published by: Springer
Stable URL: http://www.jstor.org/stable/40271822
Page Count: 7
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Dietary Intake of Carotenoids and Retinol and Endometrial Cancer Risk in an Italian Case–Control Study
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Abstract

Objectives To provide information on the relation between intake of carotenoids and retinol and endometrial cancer, since available data are inconsistent. Further, carotenoids other than beta-carotene have been rarely investigated. Methods We conducted a multi-centric case–control study in various areas of Italy between 1992 and 2006 on 454 women with incident, histologically confirmed endometrial cancer and 908 controls admitted to the same network of hospitals of cases for acute, non-neoplastic conditions. Intake of carotenoids and retinol was computed from a validated and reproducible food frequency questionnaire. We adjusted for selected covariates, including energy intake, and calculated multivariate odds ratios (OR) and 95% confidence intervals (CI) using conditional logistic regression. Results Comparing the highest to the lowest quartile of intake, the ORs of endometrial cancer were 0.69 (95% CI, 0.48- 0.99) for beta-carotene, 0.65 (95% CI, 0.45- 0.94) for beta-cryptoxanthin, and 0.59 (95% CI, 0.41- 0.85) for lutein plus zeaxanthin intake. No association emerged with retinol (OR = 1.31, 95% CI, 0.94- 1.84), alpha-carotene (OR = 0.94, 95% CI, 0.66- 1.34), and lycopene (OR = 0.95, 95% CI, 0.68- 1.34). Conclusions Our results support a favorable role of selected dietary carotenoids on endometrial cancer risk.

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