Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima

Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley M. Deacon, John Wooley, Scott A. Lesley, Ian A. Wilson, Bernhard Palsson, Andrei Osterman and Adam Godzik
Science
New Series, Vol. 325, No. 5947 (Sep. 18, 2009), pp. 1544-1549
Stable URL: http://www.jstor.org/stable/40301833
Page Count: 6
  • More info
  • Cite this Item
Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima
Preview not available

Abstract

Metabolic pathways have traditionally been described in terms of biochemical reactions and metabolites. With the use of structural genomics and systems biology, we generated a three-dimensional reconstruction of the central metabolic network of the bacterium Thermotoga marítíma. The network encompassed 478 proteins, of which 120 were determined by experiment and 358 were modeled. Structural analysis revealed that proteins forming the network are dominated by a small number (only 182) of basic shapes (folds) performing diverse but mostly related functions. Most of these folds are already present in the essential core (~30%) of the network, and its expansion by nonessential proteins is achieved with relatively few additional folds. Thus, integration of structural data with networks analysis generates insight into the function, mechanism, and evolution of biological networks.

Page Thumbnails

  • Thumbnail: Page 
1544
    1544
  • Thumbnail: Page 
1545
    1545
  • Thumbnail: Page 
1546
    1546
  • Thumbnail: Page 
1547
    1547
  • Thumbnail: Page 
1548
    1548
  • Thumbnail: Page 
1549
    1549