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Ischemic Cardiac Events during the Department of Health and Human Services Smallpox Vaccination Program, 2003
David L. Swerdlow, Martha H. Roper, Juliette Morgan, Richard A. Schieber, Laurence S. Sperling, Mercedes M. Sniadack, Linda Neff, Jacqueline W. Miller, Christine R. Curtis, Mona E. Marin, John Iskander, Pedro Moro, Paige Hightower, Nancy H. Levine, Mary McCauley, James Heffelfinger, Inger Damon, Thomas J. Török, Melinda Wharton, Eric E. Mast, Gina T. Mootrey and Smallpox Vaccine Cardiac Adverse Events Working Group
Clinical Infectious Diseases
Vol. 46, Supplement 3. Posteradication Vaccination against Smallpox (Mar. 15, 2008), pp. S234-S241
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/40307458
Page Count: 8
You can always find the topics here!Topics: Vaccination, Smallpox, Chest pain, Preventive medicine, Civilian personnel, Heart diseases, Smallpox vaccines, Myocarditis, Predisposing factors, Enzymes
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Ten ischemic cardiac events (ICEs) were reported among 37,901 initial US Department of Health and Human Services (DHHS) smallpox vaccinees. Symptoms developed a median of 10 days after vaccination (range, 0-28 days). The median age of case patients was 56 years (range, 42-65 years), and 60% were male. Seven (70%) of the case patients had ^ 3 cardiac risk factors or probable coronary artery disease before vaccination. Two women, 55 and 57 years of age, experienced acute myocardial infarction and fatal cardiac arrests. Background rates of ICEs during a 3-week period for civilian populations that were age and sex matched to DHHS vaccinees were estimated. The observed number of myocardial infarctions exceeded estimated expectations (5 vs. 2) but remained within the 95% predictive interval (PI) (0.6-5.4). New onset angina was observed significantly less frequently than estimated expectations (1 vs. 10; 95% PI, 3.5-15.7). After persons with ^ 3 cardiac risk factors or known heart disease were deferred from vaccination, no ICEs were reported among an additional 6638 vaccinees.
Clinical Infectious Diseases © 2008 Oxford University Press