Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Antimicrobial and Immunomodulatory Attributes of Statins: Relevance in Solid-Organ Transplant Recipients

Hsin-Yun Sun and Nina Singh
Clinical Infectious Diseases
Vol. 48, No. 6 (Mar. 15, 2009), pp. 745-755
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/40309031
Page Count: 11
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Antimicrobial and Immunomodulatory Attributes of Statins: Relevance in Solid-Organ Transplant Recipients
Preview not available

Abstract

Statins are increasingly being used to treat solid-organ transplant recipients for posttransplantation metabolic complications. In addition to improving dyslipidemia, statins also have manifold non-lipid-lowering effects. With regard to sepsis or infection, these agents modify the inflammatory cascades by pleiotropic actions at multiple levels and exhibit activities against opportunistic bacteria, fungi, and viruses that can cause serious infections in solid-organ transplant recipients. They also have synergistic interactions with antimicrobial agents. Statins with antimicrobial and immunomodulatory attributes might improve morbidity and mortality attributable to sepsis or infection in solid-organ transplant recipients.

Page Thumbnails

  • Thumbnail: Page 
745
    745
  • Thumbnail: Page 
746
    746
  • Thumbnail: Page 
747
    747
  • Thumbnail: Page 
[748]
    [748]
  • Thumbnail: Page 
749
    749
  • Thumbnail: Page 
750
    750
  • Thumbnail: Page 
751
    751
  • Thumbnail: Page 
752
    752
  • Thumbnail: Page 
753
    753
  • Thumbnail: Page 
754
    754
  • Thumbnail: Page 
755
    755