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Chlorination Disinfection By-Products in Drinking Water and Congenital Anomalies: Review and Meta-Analyses
Mark J. Nieuwenhuijsen, David Martinez, James Grellier, James Bennett, Nicky Best, Nina Iszatt, Martine Vrijheid and Mireille B. Toledano
Environmental Health Perspectives
Vol. 117, No. 10 (Oct., 2009), pp. 1486-1493
Published by: The National Institute of Environmental Health Sciences
Stable URL: http://www.jstor.org/stable/40382919
Page Count: 8
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Objectives: The aim of this study was to review epidemiologic evidence, provide summary risk estimates of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies, and provide recommendations for future studies. Data sources and extraction: We included all published epidemiologic studies that evaluated a relationship between an index of DBP exposure (treatment, water source, DBP measurements, and both DBP measurements and personal characteristics) and risk of congenital anomalies. When three or more studies examined the same exposure index and congenital anomaly, we conducted a mctaanalysis to obtain a summary risk estimate comparing the highest exposure group with the lowest exposure group. When five or more studies examined total trihalomethane (TTHM) exposure and a specific congenital anomaly, we conducted a meta-analysis to obtain exposure–response risk estimates per 10 μg/L TTHM. Data synthesis: For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM [17%; 95% confidence interval (CI), 3–34] based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21–107), but this was based on only three studies, and there was little evidence of an exposure-response relationship. We observed no statistically significant relationships in the other meta-analyses. We found little evidence for publication bias, except for urinary tract defects and deft lip and palate. Conclusion: Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such an association.
Environmental Health Perspectives © 2009 The National Institute of Environmental Health Sciences