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Prevalence of Hepatitis C Virus Infection in Patients with COPD
D. R. Silva, J. Stifft, H. Cheinquer and M. M. Knorst
Epidemiology and Infection
Vol. 138, No. 2 (Feb., 2010), pp. 167-173
Published by: Cambridge University Press
Stable URL: http://www.jstor.org/stable/40390543
Page Count: 7
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Some studies have suggested that chronic hepatitis C virus (HCV) infection may induce an accelerated decline of forced expiratory volume in 1 second $FEV_1 $ . We performed a cross-sectional study to determine the prevalence of HCV infection in a sample of chronic obstructive pulmonary disease (COPD) patients and in a control group of blood donors. The clinical characteristics of HCV-positive and HCV-negative patients were compared. Anti-HCV antibody was determined and confirmed by HCV-RNA. The prevalence of HCV infection in COPD patients was 7·5% (95% CI 6·52-8·48) and in blood donors was 0·41% (95% CI 0·40-0·42). The HCV-positive patients had a lower $FEV_1 $ (34·7±8·6%) and a higher BODE index (median=6) than HCV-negative patients (42·7±16·5%, median=4, respectively) (P= 0·011 and 0·027, respectively). Our results suggest a high prevalence of chronic HCV infection in patients with COPD in comparison with the blood donors. HCV-positive patients have a more severe disease.
Epidemiology and Infection © 2010 Cambridge University Press