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B7-H1 (PD-L1) on T Cells Is Required for T-Cell-Mediated Conditioning of Dendritic Cell Maturation

Oezcan Talay, Ching-Hung Shen, Lieping Chen, Jianzhu Chen and Herman N. Eisen
Proceedings of the National Academy of Sciences of the United States of America
Vol. 106, No. 8 (Feb. 24, 2009), pp. 2741-2746
Stable URL: http://www.jstor.org/stable/40421779
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
B7-H1 (PD-L1) on T Cells Is Required for T-Cell-Mediated Conditioning of Dendritic Cell Maturation
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Abstract

Studies have shown that T-cell-dendritic cell (DC) interaction is required for efficient DC maturation. However, the identities of the molecules that mediate the interaction in vivo are largely unknown. Here, we show that maturation of DCs as well as CD8 T-cell responses were impaired in B7-H1-deficient ($B7 - H1^{ - / - } $) mice to influenza virus infection. Both defects were restored by transferring B7-H1-expressing naïve T cells into $B7 - H1^{ - / - } $ mice. Similarly, transferring DCs from wild-type mice or from $RAG1^{ - / - } $ mice that had been injected with B7-H1-expressing naïve T cells also restored CD8 T-cell responses in $B7 - H1^{ - / - } $ mice. These results demonstrate that B7-H1 on naïve T cells is required to condition immature DCs to undergo efficient maturation when they encounter microbial infection. In return, the mature DCs stimulate a robust T-cell reponse against the infecting pathogen.

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