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Evolution of MRSA during Hospital Transmission and Intercontinental Spread

Simon R. Hams, Edward J. Feil, Matthew T. G. Holden, Michael A. Quail, Emma K. Nickerson, Narisara Chantratita, Susana Gardete, Ana Tavares, Nick Day, Jodi A. Lindsay, Jonathan D. Edgeworth, Herminia de Lencastre, Julian Parkhill, Sharon J. Peacock and Stephen D. Bentley
Science
New Series, Vol. 327, No. 5964 (Jan. 22, 2010), pp. 469-474
Stable URL: http://www.jstor.org/stable/40508601
Page Count: 6
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Evolution of MRSA during Hospital Transmission and Intercontinental Spread
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Abstract

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a highthroughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.

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