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Loss of MeCP2 in Aminergic Neurons Causes Cell-Autonomous Defects in Neurotransmitter Synthesis and Specific Behavioral Abnormalities
Rodney C. Samaco, Caleigh Mandel-Brehm, Hsiao-Tuan Chao, Christopher S. Ward, Sharyl L. Fyffe-Maricich, Jun Ren, Keith Hyland, Christina Thaller, Stephen M. Maricich, Peter Humphreys, John J. Greer, Alan Percy, Daniel G. Glaze, Huda Y. Zoghbi and Jeffrey L. Neul
Proceedings of the National Academy of Sciences of the United States of America
Vol. 106, No. 51 (Dec. 22, 2009), pp. 21966-21971
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/40536204
Page Count: 6
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Rett syndrome (RTT) is characterized by specific motor, cognitive, and behavioral deficits. Because several of these abnormalities occur in other disease states associated with alterations in aminergic neurotransmitters, we investigated the contribution of such alterations to RTT pathogenesis. We found that both individuals with RTT and Mecp2-null mice have lower-than-normal levels of aminergic metabolites and content. Deleting Mecp2 from either TH-positive dopaminergic and noradrenergic neurons or PET1 -positive serotonergic neurons in mice decreased corresponding neurotransmitter concentration and specific phenotypes, likely through MeCP2 regulation of rate-limiting enzymes involved in aminergic neurotransmitter production. These data support a cell-autonomous, MeCP2-dependent mechanism for the regulation of aminergic neurotransmitter synthesis contributing to unique behavioral phenotypes.
Proceedings of the National Academy of Sciences of the United States of America © 2009 National Academy of Sciences