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Recurrence of hyperemesis gravidarum across generations: population based cohort study

Åse Vikanes, Rolv Skjærven, Andrej M Grjibovski, Nina Gunnes, Siri Vangen and Per Magnus
BMJ: British Medical Journal
Vol. 340, No. 7755 (15 May 2010), p. 1071
Published by: BMJ
Stable URL: http://www.jstor.org/stable/40702033
Page Count: 1
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Abstract

STUDY QUESTION Do women and female partners of men born after pregnancies complicated by hyperemesis gravidarum (hyperemesis) have an increased risk of hyperemesis? SUMMARY ANSWER There was threefold increase in the risk of hyperemesis among daughters if their mother had had hyperemesis, whereas the female partners of men whose mothers had had hyperemesis did not have an increased risk of the condition. WHAT IS KNOWN AND WHATTHIS PAPER ADDS Women who had hyperemesis in their first pregnancy have a high risk of recurrence. The observed pattern of familial clustering across generations suggests that maternal genes are more important than fetal genes in the aetiology of hyperemesis. Environmental influences along the maternal line, however, cannot be excluded as contributing factors.

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