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Paramutation's Properties and Puzzles

Vicki L. Chandler
Science
New Series, Vol. 330, No. 6004 (29 October 2010), pp. 628-629
Stable URL: http://www.jstor.org/stable/40931708
Page Count: 2
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Abstract

Paramutation refers to the process by which homologous DNA sequences communicate in trans to establish meiotically heritable expression states. Although mechanisms are unknown, current data are consistent with the hypothesis that the establishment and heritable transmission of specific chromatin states underlies paramutation. Transcribed, noncoding tandem repeats and proteins implicated in RNA-directed transcriptional silencing in plants and yeast are required for paramutation, yet the specific molecules mediating heritable silencing remain to be determined.

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