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Cerebrospinal fluid proteins in men with chronic encephalopathy after exposure to organic solvents
Lars Barregård, Carsten Wikkelsö, Lars E Rosengren, Ann Aurell, Gunnar Thiringer, Linda Nilson, Gerd Sällsten, Kenneth G Haglid and Christian Blomstrand
Scandinavian Journal of Work, Environment & Health
Vol. 16, No. 6 (December 1990), pp. 423-427
Published by: the Scandinavian Journal of Work, Environment & Health, the Finnish Institute of Occupational Health, the Danish National Research Centre for the Working Environment, and the Norwegian National Institute of Occupational Health
Stable URL: http://www.jstor.org/stable/40965828
Page Count: 5
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Cerebrospinal fluid was examined for 23 patients with chronic toxic encephalopathy after heavy exposure to organic solvents and 23 healthy age-matched referents. No differences were found between the patients and referents with respect to the levels of albumin, immunoglobulin, prealbumin, alpha-1-antitrypsin, beta-2-microglobulin, haptoglobin, or the astroglial cell proteins S100 and glial fibrillary acidic protein in the cerebrospinal fluid. The albumin ratio was normal for both the patients and the referents. The patient group had had heavy exposure to organic solvents, but its members had not been exposed for at least one year before the study. It was concluded that, if exposure to organic solvents affects proteins in cerebrospinal fluid, such effects are probably reversible.
Scandinavian Journal of Work, Environment & Health © 1990 Scandinavian Journal of Work, Environment & Health