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Hepatic metabolism of toluene after gastrointestinal uptake in humans
Jesper Bælum, Lars Mølhave, Steen Honoré Hansen and Martin Døssing
Scandinavian Journal of Work, Environment & Health
Vol. 19, No. 1 (February 1993), pp. 55-62
Published by: the Scandinavian Journal of Work, Environment & Health, the Finnish Institute of Occupational Health, the Danish National Research Centre for the Working Environment, and the Norwegian National Institute of Occupational Health
Stable URL: http://www.jstor.org/stable/40966110
Page Count: 8
You can always find the topics here!Topics: Ethanol, Excretion, Dosage, Solvents, Liver, Pulmonary alveoli, Ingestion, Alveolar air, Drug interactions, Inhalation
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The metabolism of toluene and the influence of small doses of ethanol were measured in eight male volunteers after gastrointestinal uptake, the toluene concentration in alveolar air and the urinary excretion of hippuric acid and ortho-cresol being used as the measures of metabolism. During toluene exposure to 2 mg · min⁻¹ for 3 h the alveolar toluene concentration was 0.07 (range 0— 0.11) mg · m⁻¹; exposure to 6 mg-min⁻¹ for 30 min increased the alveolar concentration to 0.9 (range 0.03— 2.6) mg · m⁻³. Ingestion of 0.08, 0.16, and 0.32 g of ethanol per kilogram of body weight during toluene exposure of 2 mg · min⁻¹ increased the alveolar concentration within 10 min, and maximal alveolar concentrations of 5 (SD 3), 24 (SD 11), and 39 (SD 28) mg · m⁻³ were reached after 30, 60, and 90 min for the three doses, respectively. Hippuric acid excretion was only decreased by an ethanol dose of 0.32 g · kg⁻¹. Very low doses of ethanol inhibit toluene metabolism, and the procedure is sensitive enough to measure metabolic interactions between solvents and other xenobiotics in humans.
Scandinavian Journal of Work, Environment & Health © 1993 Scandinavian Journal of Work, Environment & Health