Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Hepatic metabolism of toluene after gastrointestinal uptake in humans

Jesper Bælum, Lars Mølhave, Steen Honoré Hansen and Martin Døssing
Scandinavian Journal of Work, Environment & Health
Vol. 19, No. 1 (February 1993), pp. 55-62
Stable URL: http://www.jstor.org/stable/40966110
Page Count: 8
  • Read Online (Free)
  • Download ($23.00)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Hepatic metabolism of toluene after gastrointestinal uptake in humans
Preview not available

Abstract

The metabolism of toluene and the influence of small doses of ethanol were measured in eight male volunteers after gastrointestinal uptake, the toluene concentration in alveolar air and the urinary excretion of hippuric acid and ortho-cresol being used as the measures of metabolism. During toluene exposure to 2 mg · min⁻¹ for 3 h the alveolar toluene concentration was 0.07 (range 0— 0.11) mg · m⁻¹; exposure to 6 mg-min⁻¹ for 30 min increased the alveolar concentration to 0.9 (range 0.03— 2.6) mg · m⁻³. Ingestion of 0.08, 0.16, and 0.32 g of ethanol per kilogram of body weight during toluene exposure of 2 mg · min⁻¹ increased the alveolar concentration within 10 min, and maximal alveolar concentrations of 5 (SD 3), 24 (SD 11), and 39 (SD 28) mg · m⁻³ were reached after 30, 60, and 90 min for the three doses, respectively. Hippuric acid excretion was only decreased by an ethanol dose of 0.32 g · kg⁻¹. Very low doses of ethanol inhibit toluene metabolism, and the procedure is sensitive enough to measure metabolic interactions between solvents and other xenobiotics in humans.

Page Thumbnails

  • Thumbnail: Page 
55
    55
  • Thumbnail: Page 
56
    56
  • Thumbnail: Page 
57
    57
  • Thumbnail: Page 
58
    58
  • Thumbnail: Page 
59
    59
  • Thumbnail: Page 
60
    60
  • Thumbnail: Page 
61
    61
  • Thumbnail: Page 
62
    62