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Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride in exposed workers
Hans E Welinder, Bo AG Jönsson, Jörn E Nielsen, Helene E Ottosson and Cecilia A Gustavsson
Scandinavian Journal of Work, Environment & Health
Vol. 20, No. 6 (December 1994), pp. 459-465
Published by: the Scandinavian Journal of Work, Environment & Health, the Finnish Institute of Occupational Health, the Danish National Research Centre for the Working Environment, and the Norwegian National Institute of Occupational Health
Stable URL: http://www.jstor.org/stable/40966292
Page Count: 7
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Objectives — Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride (HHPA) was studied in exposed workers. Methods — The relation between exposure to HHPA and the levels of specific immunoglobin E [(radioallergosorbent test (RAST)] and immunoglobin G (enzyme-linked immunosorbent assay) antibodies was investigated in a cross-sectional study on 95 workers from two plants using epoxy resin with HHPA as a hardener; the mean time of exposure was 7 (range 0.1—25) years. Results — The specific immunoglobin E and immunoglobin G was significantly increased in exposed workers when they were compared with unexposed workers or external referents. There was no significant difference in the number of RAST positives [N = 23 (24%)] between the groups of workers exposed to < 10 μg · m⁻³ , 10—< 50 μg · m⁻³, or ≥50 μg · m⁻³. No effects were found of atopy or smoking habits on the prevalence of RAST positives. Five out of seven workers positive for immunoglobulin E in the group with the lowest exposures reported frequent short-time (minutes per day) exposures exceeding 50 μg · m⁻³. A correlation was seen between specific immunoglobulin E and G antibodies (rs = 0.5). Conclusions — The results indicate that HHPA is a sensitizing compound even at low exposure levels and that short-time peak exposures may have an impact on immunoglobulin E sensitization.
Scandinavian Journal of Work, Environment & Health © 1994 Scandinavian Journal of Work, Environment & Health