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Case-Only Analysis of Treatment-Covariate Interactions in Clinical Trials

E. Vittinghoff and D. C. Bauer
Biometrics
Vol. 62, No. 3 (Sep., 2006), pp. 769-776
Stable URL: http://www.jstor.org/stable/4124586
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Case-Only Analysis of Treatment-Covariate Interactions in Clinical Trials
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Abstract

Differential effectiveness of treatments across subgroups defined by pretreatment variables are of increasing interest, particularly in the expanding research field of pharmacogenomics. When the pretreatment variable is difficult to obtain or expensive to measure, but can be assessed at the end of the study using stored samples, nested case-control and case-cohort methods can be used to reduce costs in large efficacy trials with rare outcomes. Case-only methods are even more efficient, and reliable under a range of circumstances.

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