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Case-Only Analysis of Treatment-Covariate Interactions in Clinical Trials
E. Vittinghoff and D. C. Bauer
Vol. 62, No. 3 (Sep., 2006), pp. 769-776
Published by: International Biometric Society
Stable URL: http://www.jstor.org/stable/4124586
Page Count: 8
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Differential effectiveness of treatments across subgroups defined by pretreatment variables are of increasing interest, particularly in the expanding research field of pharmacogenomics. When the pretreatment variable is difficult to obtain or expensive to measure, but can be assessed at the end of the study using stored samples, nested case-control and case-cohort methods can be used to reduce costs in large efficacy trials with rare outcomes. Case-only methods are even more efficient, and reliable under a range of circumstances.
Biometrics © 2006 International Biometric Society