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Complete Map of Cystic Fibrosis Mutation DF508 Frequencies in Western Europe and Correlation between Mutation Frequencies and Incidence of Disease

GÉRARD LUCOTTE, SERGE HAZOUT and MARC DE BRAEKELEER
Human Biology
Vol. 67, No. 5 (October 1995), pp. 797-803
Stable URL: http://www.jstor.org/stable/41465429
Page Count: 7
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Complete Map of Cystic Fibrosis Mutation DF508 Frequencies in Western Europe and Correlation between Mutation Frequencies and Incidence of Disease
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Abstract

The frequencies of DF508, the main cystic fibrosis mutation, vary among different populations in Western Europe; they are higher in northwestern Europeans than in southeastern populations. Our new analysis is based on results from 66 different laboratories on 17,886 cystic fibrosis chromosomes (from 70 locations and 26 countries). The correlation between DF508 frequency values and cystic fibrosis incidence is calculated in the corresponding groups.

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