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G542X As a Probable Phoenician Cystic Fibrosis Mutation
FRANCE LOIRAT, SERGE HAZOUT and GÉRARD LUCOTTE
Vol. 69, No. 3 (June 1997), pp. 419-425
Published by: Wayne State University Press
Stable URL: http://www.jstor.org/stable/41465564
Page Count: 7
You can always find the topics here!Topics: Genetic mutation, Cystic fibrosis, Chromosomes, Towns, Maps, Geographic regions, Genes, Genetics, Coordinate systems, High frequencies
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When analyzed by origin, the frequency of the G542X cystic fibrosis (CF) mutation (the second most common CF mutation in Europe after DF508) varies between population groups in Europe. We show here that the frequency of G542X varies among different towns or regions of origin, being lower in northeastern Europeans than in southwestern Europeans. The G542X mutation mapping that we have defined by a multiple regression of G542X frequencies covers 28 countries (53 geographic points) and is based on data from 50 laboratories. The more elevated values of G542X frequency correspond to ancient sites of occupation by occidental Phoenicians.
Human Biology © 1997 Wayne State University Press