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Genotype Associations among Seven Apolipoprotein B Polymorphisms in a Populatioin of Orang Asli of Western Malaysia
B. GAJRA, J.K. CANDLISH, C.K. HENG, J.W. MAK and N. SAHA
Vol. 69, No. 5 (October 1997), pp. 629-640
Published by: Wayne State University Press
Stable URL: http://www.jstor.org/stable/41465587
Page Count: 12
You can always find the topics here!Topics: Haplotypes, Alleles, Evolution, DNA, Asians, Coronary artery disease, Linkage disequilibrium, Genetic mutation, Lipoproteins, Blood lipids
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Associations among seven apolipoprotein B (APOB) gene polymorphisms [C-T promoter site; Leu-Ala-Leu signal peptide (SP) insertion/deletion; AG C, G site at codon 71; AG A1, D site at codon 591; XbaI site at codon 2488; AG H,I site at codon 3611; and AG T, Z site at codon 4154] were investigated in 195 members of an Orang Asli (aborigine) population from western Malaysia. Frequencies of the rare alleles for all these polymorphisms turned out to be low when compared with European but not Asian populations. The AG H,I site was not polymorphic. The highly polymorphic sites are in linkage disequilibrium among themselves, as shown by their Δ values: SP 24,27 and AG C,G, 0.68; SP 24,27 and AG A1,D, 0.71; XbaI and AG C, G, 0.64; XbaI and AG A1, D, 0.57; SP 24,27 and XbaI 0.48; and AG C, G and AG A1, D, 0.68. Ten unequivocal haplotypes on the basis of six sites (excluding the promoter polymorphism) were observed, and they represent 80% of the sample. The frequency of haplotype SP27,G,A1,X–,I,T, defined by the common homozygotes at all the sites for the gene was 0.7, compared with 0.22 in Europeans. The ancestral haplotype SP27,G,D,X–,I,T was present at low frequency (0.01) in both the Orang Asli and Europeans. A cladogram constructed on the basis of haplotypes in the Orang Asli shows two different lines of evolution and that other haplotypes evolved by subsequent mutations on the ancestral haplotype.
Human Biology © 1997 Wayne State University Press