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Molecular Approaches to the Genetic Analysis of Specific Reading Disability
SHELLEY D. SMITH, PHILIP M. KELLEY and AMY M. BROWER
Vol. 70, No. 2, Special Issue on Human Behavioral Genetics: Synthesis of Quantitative and Molecular Approaches (April 1998), pp. 239-256
Published by: Wayne State University Press
Stable URL: http://www.jstor.org/stable/41465637
Page Count: 18
You can always find the topics here!Topics: Phenotypes, Reading difficulties, Genetics, Genes, Chromosomes, Phenotypic traits, DNA, Complementary DNA, Alleles, Lod score
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Specific reading disability is a complex phenotype that is under both genetic and environmental influences. There is evidence for at least one major gene, which may be detectable by parametric linkage analysis, but detection of other quantitative trait loci may require nonparametric methods. Phenotype definition may also be critical in identifying genes that affect different components of the reading process. Current research from two separate laboratories supports the localization of one gene influencing reading disability to the histocompatibility region of chromosome 6p and suggests that another gene may be located on chromosome 15. Actual identification of these and similar genes is complicated by reduced penetrance and phenocopies in families, so that delineation of the critical region using crossover analysis is problematic. This difficulty can result in the identification of many candidate genes that need to be evaluated through combinations of association analysis, functional analysis, and mutation assays.
Human Biology © 1998 Wayne State University Press