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Some Atypical and Rare Sickle Cell Gene Haplotypes in Populations of Andhra Pradesh, India

Y. NIRANJAN, G.R. CHANDAK, P. VEERRAJU and LALJI SINGH
Human Biology
Vol. 71, No. 3 (June 1999), pp. 333-340
Stable URL: http://www.jstor.org/stable/41465743
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Some Atypical and Rare Sickle Cell Gene Haplotypes in Populations of Andhra Pradesh, India
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Abstract

We have investigated the clinical, hematological, and molecular genetic characteristics of sickle cell anemia patients from 6 populations of Andhra Pradesh, South India. Of 72 sickle cell chromosomes (HBB*S) 60 belong to characteristic Arab-Indian haplotypes, 6 to variant Arab-Indian haplotypes, 1 to a Bantu haplotype, 2 to a Cameroon haplotype, and 3 to rare haplotypes. This is the first report of a Bantu haplotype in an Indian population. Some information on haplotype characteristics of normal chromosomes (HBB*A) is also presented. The average hemoglobin level was 7.3 g% and mean fetal hemoglobin (HbF) level was 12.6%. The higher HbF levels corroborate earlier observations in sickle cell homozygotes from India. Clinical investigations have revealed splenomegaly and painful crises as the most common features in these patients.

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