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Some Atypical and Rare Sickle Cell Gene Haplotypes in Populations of Andhra Pradesh, India
Y. NIRANJAN, G.R. CHANDAK, P. VEERRAJU and LALJI SINGH
Vol. 71, No. 3 (June 1999), pp. 333-340
Published by: Wayne State University Press
Stable URL: http://www.jstor.org/stable/41465743
Page Count: 8
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We have investigated the clinical, hematological, and molecular genetic characteristics of sickle cell anemia patients from 6 populations of Andhra Pradesh, South India. Of 72 sickle cell chromosomes (HBB*S) 60 belong to characteristic Arab-Indian haplotypes, 6 to variant Arab-Indian haplotypes, 1 to a Bantu haplotype, 2 to a Cameroon haplotype, and 3 to rare haplotypes. This is the first report of a Bantu haplotype in an Indian population. Some information on haplotype characteristics of normal chromosomes (HBB*A) is also presented. The average hemoglobin level was 7.3 g% and mean fetal hemoglobin (HbF) level was 12.6%. The higher HbF levels corroborate earlier observations in sickle cell homozygotes from India. Clinical investigations have revealed splenomegaly and painful crises as the most common features in these patients.
Human Biology © 1999 Wayne State University Press