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HLA-DQA1 and HLA-DQB1 Alleles and Haplotypes in Two Brazilian Indian Tribes: Evidence of Conservative Evolution of HLA-DQ
V.S. SOTOMAIOR, F.R. FAUCZ, C. SCHAFHAUSER, M. JANZEN-DÜCK, A.B.W. BOLDT and M.L. PETZL-ERLER
Vol. 70, No. 4 (August 1998), pp. 789-797
Published by: Wayne State University Press
Stable URL: http://www.jstor.org/stable/41466801
Page Count: 9
You can always find the topics here!Topics: Alleles, Haplotypes, HLA antigens, Evolution, Genetic loci, Native Americans, Linkage disequilibrium, Admixtures, HLA B antigens, Genetic drift
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Nucleotide sequence polymorphism of the HLA-DQA1 and HLA-DQB1 class II genes was analyzed in the Kaingang and Guarani Amerindians from southern Brazil using PCR sequence-specific oligonucleotide typing methods. Four different DQA1-DQB1 haplotypes were found: DQA1*0401-DQB1*0402 (associated with DRB1*0802, DRB1*08041, and DRB1*0807), DQA1*0501-DQB1*0301 (associated with DRB1*16O2, DRB1*1413, and DRB1*14O2), DQA1*O3-DQB1*0302 (associated with DRB1*0404 and DRB1*O411) and DQA1*03-DQB1*03032 (associated with DRB1*09012). These HLA-DQA1 and HLA-DQB1 alíeles and haplotypes are common in many other populations of all major ethnic groups. Alíeles and haplotypes introduced into the populations by post-Columbian admixture were seen at low frequency both in the Kaingang (3.2%) and in the Guarani (3.8%). No novel HLA-DQA1 and HLA-DQB1 alleles have thus far been identified in Amerindians. This differs from previous results for HLA-DRB1, another class II locus presenting novel alleles (i. e., alleles not found in other ethnic groups and probably generated after migration of paleo-Indians to the Americas) in the Guarani and in other South American Indian populations. The distribution of the HLA-DQ alíeles and haplotypes in Amerindians indicates a weaker diversifying selective pressure on the HLA-DQ genes compared with HLA-DRB1 and HLA-B. The more conservative evolution of HLA-DQA1 and HLA-DQB1 compared with HLA-DRB1 is strong evidence of (still not well-defined) functional differences of these class II genes.
Human Biology © 1998 Wayne State University Press