You are not currently logged in.
Access JSTOR through your library or other institution:
Associations of serum vitamin A and carotenoid levels with markers of prostate cancer detection among US men
Hind A. Beydoun, Monal R. Shroff, Ravinder Mohan and May A. Beydoun
Cancer Causes & Control
Vol. 22, No. 11 (November 2011), pp. 1483-1495
Published by: Springer
Stable URL: http://www.jstor.org/stable/41485375
Page Count: 13
You can always find the topics here!Topics: Carotenoids, Prostate cancer, Antigens, Biological markers, Esters, Prostate, Vitamin A, High schools, Health surveys, Antioxidants
Were these topics helpful?See something inaccurate? Let us know!
Select the topics that are inaccurate.
Preview not available
Associations of serum vitamin A and carotenoid levels with markers of prostate cancer detection were evaluated among 3,927 US men, 40-85 years of age, who participated in the 2001-2006 National Health and Nutrition Examination Surveys. Five recommended definitions of prostate cancer detection were adopted using total and free prostate-specific antigen (tPSA and fPSA) laboratory measurements. Men were identified as high risk based on alternative cutoffs, namely tPSA > 10 ng/ml, tPSA > 4 ng/ml, tPSA > 2.5 ng/ml, % fPSA < 25%, and % fPSA < 15%. % fPSA was defined as (fPSA ÷ tPSA) x 100%. Serum levels of vitamin A (retinol and retinyl esters) and carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein + zeaxanthin, lycopene) were defined as quartiles and examined as risk/protective factors for PSA biomarkers. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using binary logistic models. After adjustment for known demographic, socioeconomic, and lifestyle confounders, high serum levels of retinyl esters (tPSA > 10 ng/ml: Q4 vs. Q1 → OR = 0.38, 95% CI: 0.14-1.00) and α-carotene (% fPSA < 15%: Q4 vs. Q1 → OR = 0.49, 95% CI: 0.32-0.76) were associated with a lower odds, whereas high serum level of lycopene (tPSA > 2.5 ng/ml: Q4 vs. Q1 → OR = 1.49, 95% CI: 1.01-2.14) was associated with a greater odds of prostate cancer detection. Apart from the three significant associations observed, no other exposure-outcome association was significant. Monitoring specific antioxidant levels may be helpful in the early detection of prostate cancer.
Cancer Causes & Control © 2011 Springer