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The Structure of Mitogen-Activated Protein Kinase p38 at 2.1- angstrom Resolution

Zhulun Wang, Paul C. Harkins, Richard J. Ulevitch, Jiahuai Han, Melanie H. Cobb and Elizabeth J. Goldsmith
Proceedings of the National Academy of Sciences of the United States of America
Vol. 94, No. 6 (Mar. 18, 1997), pp. 2327-2332
Stable URL: http://www.jstor.org/stable/41637
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
The Structure of Mitogen-Activated Protein Kinase p38 at 2.1- angstrom Resolution
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Abstract

The structure of mitogen-activated protein (MAP) kinase p38 has been solved at 2.1- angstrom to an R factor of 21.0%, making p38 the second low activity MAP kinase solved to date. Although p38 is topologically similar to the MAP kinase ERK2, the phosphorylation Lip (a regulatory loop near the active site) adopts a different fold in p38. The peptide substrate binding site and the ATP binding site are also different from those of ERK2. The results explain why MAP kinases are specific for different activating enzymes, substrates, and inhibitors. A model presented for substrate and activator interactions has implications for the evolution of protein kinase cascades.

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