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The interaction of HspA1A with TLR2 and TLR4 in the response of neutrophils induced by ovarian cancer cells in vitro

Magdalena Klink, Marek Nowak, Michał Kielbik, Katarzyna Bednarska, Edyta Blus, Marian Szpakowski, Krzysztof Szyllo and Zofia Sulowska
Cell Stress & Chaperones
Vol. 17, No. 6 (NOVEMBER 2012), pp. 661-674
Published by: Cell Stress Society International in partnership with Springer
Stable URL: http://www.jstor.org/stable/41759274
Page Count: 14
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Abstract

Inducible heat shock protein (HspA1A) promotes tumor cell growth and survival. It also interacts with effector cells of the innate immune system and affects their activity. Recently, we showed that the direct contact of ovarian cancer cells, isolated from tumor specimens, with neutrophils intensified their biological functions. Our current experiments demonstrate that the activation of neutrophils, followed by an increased production of reactive oxygen species, by cancer cells involves the interaction of HspA1A from cancer cells with Toll-like receptors 2 and 4 expressed on the neutrophils' surface. Our data may have a practical implication for targeted anticancer therapies based, among other factors, on the inhibition of HspA1A expression in the cancer cells.

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