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Journal Article

Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae)

H. Tunón, W. Thorsell and L. Bohlin
Economic Botany
Vol. 48, No. 2 (Apr. - Jun., 1994), pp. 111-120
Published by: Springer on behalf of New York Botanical Garden Press
Stable URL: http://www.jstor.org/stable/4255595
Page Count: 10

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Topics: Mosquitos, Esters, Ethanol, Catechols, Carboxylic acids, Economic botany, Plants, Ethers, Reagents, Petroleum ether
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Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae)
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Abstract

An ethanol extract of Achillea millefolium L. showed repelling properties against the mosquito, Aedes aegypti L. Prepared fractions from the extract contained several active compounds which were characterized by thin layer chromatography, high performance liquid chromatography, gas chromatography and mass spectroscopy. Of 35 compounds tested, the most active were the nitrogen containing compound stachydrine, the carboxylic acids, caffeic, chlorogenic, and salicylic acids, and the phenolic compound pyrocatechol. These substances are earlier reported to occur in A. millefolium with the exception of pyrocatechol. Some further substances with lower activity were characterized for the first time in A. millefolium, i.e., adenine, ferulic and mandelic acid, and the methyl esters of caprylic-, linolenic- and undecylenic acid. / Der Ethanolextrakt von A. millefolium zeigte abwehrende Eigenschaften gegen die Mücke Aedes aegypti L. Die aus diesem Extrakt hergestellten Fraktionen enthielten mehrere aktive Verbindungen, die mittels Dünnschichtchromatographie, Gaschromatographie und Massenspektrometrie charakterisiert wurden. Von den 35 untersuchten Substanzen waren die stickstoffhaltige Verbindung Stachydrin, die sauren Verbindungen Kaffe-, Chlorogen- und Salicylsäure sowie das Brenzcatechin die aktivsten. Diese Substanzen sind mit Ausnahme des Brenzcatechins schon früher aus A. millefolium beschrieben worden. Weiterhin wurden Adenin, Ferula- und Mandelsäure sowie die Methylestern der Capryl-, Linolen- und Undecylensäure als schwächer aktive Substanzen zum ersten Mal aus A. millefolium charakterisiert.

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