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Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples
Maria Pangalos, José R. Donoso, Jochen Winterer, Aleksandar R. Zivkovic, Richard Kempter, Nikolaus Maier and Dietmar Schmitz
Proceedings of the National Academy of Sciences of the United States of America
Vol. 110, No. 11 (March 12, 2013), pp. 4398-4403
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/42583260
Page Count: 6
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Sharp wave-associated ~200-Hz ripple oscillations in the hippocampus have been implicated in the consolidation of memories. However, knowledge on mechanisms underlying ripples is still scarce, in particular with respect to synaptic involvement of specific cell types. Here, we used cell-attached and whole-cell recordings in vitro to study activity of pyramidal cells and oriens-lacunosum-moleculare (O-LM) interneurons during ripples. O-LM cells received ripple-associated synaptic input that arrived delayed (3.3 ± 0.3 ms) with respect to the maximum amplitude of field ripples and was locked to the ascending phase of field oscillations (mean phase: 209 ± 6°). In line, O-LM cells episodically discharged late during ripples (~6.5 ms after the ripple maximum), and firing was phaselocked to field oscillations (mean phase: 219 ± 9°). Our data unveil recruitment of O-LM neurons during ripples, suggesting a previously uncharacterized role of this cell type during sharp wave-associated activity.
Proceedings of the National Academy of Sciences of the United States of America © 2013 National Academy of Sciences