Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples

Maria Pangalos, José R. Donoso, Jochen Winterer, Aleksandar R. Zivkovic, Richard Kempter, Nikolaus Maier and Dietmar Schmitz
Proceedings of the National Academy of Sciences of the United States of America
Vol. 110, No. 11 (March 12, 2013), pp. 4398-4403
Stable URL: http://www.jstor.org/stable/42583260
Page Count: 6
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples
Preview not available

Abstract

Sharp wave-associated ~200-Hz ripple oscillations in the hippocampus have been implicated in the consolidation of memories. However, knowledge on mechanisms underlying ripples is still scarce, in particular with respect to synaptic involvement of specific cell types. Here, we used cell-attached and whole-cell recordings in vitro to study activity of pyramidal cells and oriens-lacunosum-moleculare (O-LM) interneurons during ripples. O-LM cells received ripple-associated synaptic input that arrived delayed (3.3 ± 0.3 ms) with respect to the maximum amplitude of field ripples and was locked to the ascending phase of field oscillations (mean phase: 209 ± 6°). In line, O-LM cells episodically discharged late during ripples (~6.5 ms after the ripple maximum), and firing was phaselocked to field oscillations (mean phase: 219 ± 9°). Our data unveil recruitment of O-LM neurons during ripples, suggesting a previously uncharacterized role of this cell type during sharp wave-associated activity.

Page Thumbnails

  • Thumbnail: Page 
[4398]
    [4398]
  • Thumbnail: Page 
4399
    4399
  • Thumbnail: Page 
4400
    4400
  • Thumbnail: Page 
4401
    4401
  • Thumbnail: Page 
4402
    4402
  • Thumbnail: Page 
4403
    4403