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Effect of Opioids on Tissue Metabolism in Aestivating and Active Green-Striped Burrowing Frogs, Cyclorana alboguttata
Sara M. Kayes, Rebecca L. Cramp, Nicholas J. Hudson and Craig E. Franklin
Journal of Herpetology
Vol. 47, No. 2 (June 2013), pp. 369-377
Published by: Society for the Study of Amphibians and Reptiles
Stable URL: http://www.jstor.org/stable/43287356
Page Count: 9
You can always find the topics here!Topics: Opioid analgesics, Metabolism, Hibernation, Opioid receptors, Genetic variation, Aestivation, Agonists, Liver, Muscles, Receptors
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Metabolic depression is a common strategy used during stressful environmental conditions, allowing animals to survive for prolonged periods on limited endogenous fuel stores; yet, the mechanisms involved in regulating metabolic depression are poorly understood. The endogenous opioid system (EOS) has been implicated in the regulation of metabolism during hibernation in vertebrates, and we hypothesized that opioids also may regulate metabolic rate during aestivation in the Green-Striped Burrowing Frog, Cyclorana (Litoria) alboguttata (Günther, 1867). When incubated in the presence of opioid agonists, liver and muscle tissue slices from C. alboguttata underwent tissue-and agonist-specific metabolic depression, and the effect of opioid agonists on metabolism was more pronounced in tissue slices from aestivating animals. Gene transcript levels for the δ-opioid receptor remained constant in the brain and muscle of aestivating C. alboguttata compared with that of active frogs, as did brain transcript levels of the opioid receptor XOR1. The results of this study demonstrate that opioids can influence metabolic rate in isolated tissues from alboguttata. The maintenance of key opioid receptor gene transcript levels in tissues of aestivating frogs suggests that despite the energetic costs, maintenance of receptor abundance is important. We propose that the maintenance of opioid receptor abundance during aestivation in C. alboguttata is indicative of a role for the EOS in the regulation of metabolic rate during aestivation.
Journal of Herpetology © 2013 Society for the Study of Amphibians and Reptiles