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hSK4, a Member of a Novel Subfamily of Calcium-Activated Potassium Channels
William J. Joiner, Lu-Yang Wang, Michael D. Tang and Leonard K. Kaczmarek
Proceedings of the National Academy of Sciences of the United States of America
Vol. 94, No. 20 (Sep. 30, 1997), pp. 11013-11018
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/43456
Page Count: 6
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The gene for hSK4, a novel human small conductance calcium-activated potassium channel, or SK channel, has been identified and expressed in Chinese hamster ovary cells. In physiological saline hSK4 generates a conductance of approximately 12 pS, a value in close agreement with that of other cloned SK channels. Like other members of this family, the polypeptide encoded by hSK4 contains a previously unnoted leucine zipper-like domain in its C terminus of unknown function. hSK4 appears unique, however, in its very high affinity for Ca2+ (EC50 of 95 nM) and its predominant expression in nonexcitable tissues of adult animals. Together with the relatively low homology of hSK4 to other SK channel polypeptides (approximately 40% identical), these data suggest that hSK4 belongs to a novel subfamily of SK channels.
Proceedings of the National Academy of Sciences of the United States of America © 1997 National Academy of Sciences