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Cloning and Characterization of a Corepressor and Potential Component of the Nuclear Hormone Receptor Repression Complex

Iris Zamir, Jessica Dawson, Robert M. Lavinsky, Christopher K. Glass, Michael G. Rosenfeld and Mitchell A. Lazar
Proceedings of the National Academy of Sciences of the United States of America
Vol. 94, No. 26 (Dec. 23, 1997), pp. 14400-14405
Stable URL: http://www.jstor.org/stable/43629
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Cloning and Characterization of a Corepressor and Potential Component of the Nuclear Hormone Receptor Repression Complex
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Abstract

Nuclear hormone receptors are potent repressors of transcription in the unliganded state. We describe here the cloning of a nuclear receptor corepressor that we call SUN-CoR (Small Unique Nuclear receptor CoRepressor), which shows no homology to previously described nuclear hormone receptor corepressors, N-CoR, or SMRT. SUN-CoR is a highly basic, 16-kDa nuclear protein that is expressed at high levels in adult tissues and is induced during adipocyte and myogenic differentiation. SUN-CoR potentiates transcriptional repression by thyroid hormone receptor and RevErb in vivo, represses transcription when fused to a heterologous DNA binding domain, and interacts with RevErb as well as with thyroid hormone receptor in vitro. SUN-CoR also interacts with N-CoR and SMRT in vitro and with endogenous N-CoR in cells. We conclude that SUN-CoR is a corepressor and may function as an additional component of the complex involved in transcriptional repression by unliganded and orphan nuclear hormone receptors.

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