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Neurotransmitter Receptor Imaging in Living Human Brain with Positron Emission Tomography

Stephen M. Stahl, Rosario Moratalla and Norman G. Bowery
The Journal of Mind and Behavior
Vol. 9, No. 3, SPECIAL ISSUE: NEURORADIOLOGY: APPLICATIONS IN NEUROLOGY AND NEUROSURGERY (Summer 1988), pp. 367-384
Stable URL: http://www.jstor.org/stable/43853452
Page Count: 18
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Neurotransmitter Receptor Imaging in Living Human Brain with Positron Emission Tomography
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Abstract

New neuroimaging technology can label specific receptors in living human brain with ligands tagged with radio-isotopes, and then anatomically localize and quantitate them with positron emission tomography (PET). This approach requires a multidisciplinary team, including radiochemists who prepare tagged ligands, pharmacologists who develop in vitro and ex vivo techniques for quantitating receptors in experimental animals, and PET experts who adapt these techniques for in vivo study of human subjects. This article outlines the principles of quantitative PET analysis by examining the numerous biochemical, kinetic and anatomical methods available for neurotransmitter receptor quantitation in experimental animals, as well as their applications to the study of neurotransmitter receptors in living human brain with PET.

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