Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Targeted Deletion of Smad4 Shows it is Required for Transforming Growth Factor β and Activin Signaling in Colorectal Cancer Cells

Shibin Zhou, Phillip Buckhaults, Leigh Zawel, Fred Bunz, Greg Riggins, Jia Le Dai, Scott E. Kern, Kenneth W. Kinzler and Bert Vogelstein
Proceedings of the National Academy of Sciences of the United States of America
Vol. 95, No. 5 (Mar. 3, 1998), pp. 2412-2416
Stable URL: http://www.jstor.org/stable/44064
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Targeted Deletion of Smad4 Shows it is Required for Transforming Growth Factor β  and Activin Signaling in Colorectal Cancer Cells
Preview not available

Abstract

Smad4 (DPC4) is a candidate tumor suppressor gene that has been hypothesized to be critical for transmitting signals from transforming growth factor (TGF) β and related ligands. To directly test this hypothesis, the Smad4 gene was deleted through homologous recombination in human colorectal cancer cells. This deletion abrogated signaling from TFG-β as well as from the TGF-β family member activin. These results provide unequivocal evidence that mutational inactivation of Smad4 causes TGF-β unresponsiveness and provide a basis for understanding the physiologic role of this gene in tumorigenesis.

Page Thumbnails

  • Thumbnail: Page 
2412
    2412
  • Thumbnail: Page 
2413
    2413
  • Thumbnail: Page 
2414
    2414
  • Thumbnail: Page 
2415
    2415
  • Thumbnail: Page 
2416
    2416