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Serologic Responses and Systemic Reactions in Adults after Vaccination with Monovalent A/USSR/77 and Trivalent A/USSR/77, A/Texas/77, B/Hong Kong/72 Influenza Vaccines

Gerald V. Quinnan, Robert Schooley, Raphael Dolin, Francis A. Ennis, Peter Gross and Jack M. Gwaltney
Reviews of Infectious Diseases
Vol. 5, No. 4 (Jul. - Aug., 1983), pp. 748-757
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4453127
Page Count: 10
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Serologic Responses and Systemic Reactions in Adults after Vaccination with Monovalent A/USSR/77 and Trivalent A/USSR/77, A/Texas/77, B/Hong Kong/72 Influenza Vaccines
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Abstract

Four hundred twenty-six volunteers aged 16 to 83 years were given experimental doses of inactivated monovalent [A/USSR/77 (H1N1)] and trivalent [A/USSR/77 (H1N1), A/Texas/77 (H3N2), B/Hong Kong/72] influenza vaccines as part of a double-blinded, placebo-controlled, national collaborative study. Local reactions at inoculation sites occurred in <6.6% of volunteers. Systemic reactions, generally consisting of low-grade fever, myalgia, or headache, lasting <24 hr, did not occur more frequently in vaccinees than in placebo recipients. Vaccines containing lower doses of the A/Texas/77 (H3N2) hemagglutinin (8-10 μg) and B/Hong Kong/72 hemagglutinin (6-9 μg) produced hemagglutinin-inhibiting (HAI) antibody responses equivalent to those produced by higher doses (15-28 and 19-28 μg, respectively) in all age groups. Single injections of vaccines containing lower doses of A/USSR/77 (H1N1) hemagglutinin (4-7 μg) induced titers of HAI antibody of >1:40 in 93% of volunteers ≥26 years of age but in only 58% of volunteers <26 years of age. In this latter group, two injections containing higher doses (10-19 μg) induced better antibody responses. Vaccines containing approximately 6-15 μg of hemagglutinin of each antigen can be expected to be well tolerated and to induce good HAI antibody responses in a one- or two-dose regimen, depending on the age group.

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