Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If you need an accessible version of this item please contact JSTOR User Support

Rifampin: Mechanisms of Action and Resistance

Walter Wehrli
Reviews of Infectious Diseases
Vol. 5, Supplement 3. The Use of Rifampin in the Treatment of Nontuberculous Infections (Jul. - Aug., 1983), pp. S407-S411
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4453139
Page Count: 5
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
If you need an accessible version of this item please contact JSTOR User Support
Rifampin: Mechanisms of Action and Resistance
Preview not available

Abstract

Rifampin specifically inhibits bacterial RNA polymerase, the enzyme responsible for DNA transcription, by forming a stable drug-enzyme complex with a binding constant of 10⁻⁹ M at 37 C. The corresponding mammalian enzymes are not affected by rifampin. Bacterial resistance to rifampin is caused by mutations leading to a change in the structure of the β subunit of RNA polymerase. Such resistance is not an all-or-nothing phenomenon; rather, a large number of RNA polymerases with various degrees of sensitivity to rifampin have been found. No strict correlation exists between enzyme sensitivity and MIC values, since inhibition of RNA synthesis does not always show up to the same extent in the two different test systems used for the determination of these values.

Page Thumbnails

  • Thumbnail: Page 
S407
    S407
  • Thumbnail: Page 
S408
    S408
  • Thumbnail: Page 
S409
    S409
  • Thumbnail: Page 
S410
    S410
  • Thumbnail: Page 
S411
    S411